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Yrd.Doç.Dr Özkan Özden
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SCI and SCI-expanded publications: 880 citations (Web of Science)

1. NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway. Jana A, Krett NL, Guzman G, Khalid A, Ozden O, Staudacher JJ, Bauer J, Baik SH, Carroll T, Yazici C, Jung B. Oncotarget. 2017 Jun 6;8(23):37377-37393. doi: 10.18632/oncotarget.16343.

2. Seong Hoon Park, OZDEN OZKAN, Liu Guoxiang, Song Ha Yong,Zhu Yueming, Yan Yufan, Zou Xianghui, Kang Hong Jun, Jiang Haiyan, Principe Daniel R, Cha Yong II, Roh Meejeon, Vassilopoulos Athanassios, Gius David (2016). SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth. Cancer Research, Doi: 10.1158/0008-5472.CAN-15-2498.

3. OZDEN OZKAN, Bishehsari Faraz, Bauer Jessica, Park SeongHoon, Jana Arundhati, Baik Seung Hyun, Sporn Judith, Staudacher Jonas J, Yazici Cemal, Krett Nancy, Jung Barbara (2016). Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer. Scientific Reports, 6, 26273, Doi: 10.1038/srep26273

4. Bauer Jessica, OZDEN OZKAN, Akagi Naomi, Carroll Timothy, Principe Daniel, Staudacher Jonas, Spehlman Martina, Echman Lars, Grippo Paul, Jung Barbara (2015). Activin and TGFb use diverging mitogenic signaling in advanced colon cancer. Molecular Cancer, 14(1), 1-14., Doi: 10.1186/s12943-015-0456-4.

5. OZDEN OZKAN (2015). SIRT2 - JAK1 Interaction Decreases IL-6 Induced Inflammatory Response in Cancer Cells. Kafkas Universitesi Veteriner Fakultesi Dergisi, 21(6), 813-817., 10.9775/kvfd.2015.13424.

6. Tao Randa, Jamie Leclerc, Yildiz Kubra, Seong Hoon Park, Barbara Jung, Gius David, OZDEN OZKAN (2015). Changes in gene expression in SIRT3 knockout liver cells. Turkish Journal of Biology, 39, 380-387., Doi: 10.3906/biy-1408-40. (Corresponding Author).

7. OZDEN OZKAN, Park Seong-Hoon, Wagner Brett A, Yong Song Ha, Zhu Yueming, Vassilopoulos Athanassios, Jung Barbara, Buettner Garry R, Gius David (2014). SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells. Free Radical Biology and Medicine, 76, 163-172., Doi: 10.1016/j.freeradbiomed.2014.08.001.

8. Zhu Yueming, Park Seong-Hoon, OZDEN OZKAN, Kim Hyun-Seok, Jiang Haiyan, Vassilopoulos Athanassios, Spitz Douglas R, Gius David (2012). Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radical Biology and Medicine, 53(4), 828-833., Doi: 10.1016/j.freeradbiomed.2012.06.020

9. Seong-Hoon Park, Zhu Yuming, OZDEN OZKAN, Kim Hyun-Seok, Jiang Haiyan, Deng Chu-Xia, Gius David,Vassilopoulos Athanassios (2012). SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Translational Cancer Research, 1(1), 15-21.

10. Park Seong-Hoon, OZDEN OZKAN, Jiang Haiyan, Cha Yong I, Pennington J Daniel, Aykin-Burns Nukhet, Spitz Douglas R, Gius David (2011). Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis. International Journal of Molecular Sciences, 12(12), 6226-6239., Doi: 10.3390/ijms12096226.

11. OZDEN OZKAN, Park Seong-Hoon, Kim Hyun-Seok, Jiang Haiyan, Coleman Mitchell C, Spitz Douglas R, Gius David (2011). Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging, 3(2), 102-107.  

12. Tao Randa, Coleman Mitchell C, Pennington J Daniel, OZDEN OZKAN, Park Seong- Hoon,Jiang Haiyan, Kim Hyun-Seok,Flynn Charles Robb,Hill Salisha,Hayes McDonald W,Olivier Alicia K,Spitz Douglas R,Gius David (2010). Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress. Molecular Cell, 40(6), 893-904., Doi: 10.1016/j.molcel.2010.12.013.

13. OZDEN OZKAN, Black Betty L, Ashwell Christopher M, Tipsmark Christian K, Borski Russell J, Grubb Brenda J (2010). Developmental Profile of Claudin-3, -5, and -16 Proteins in the Epithelium of Chick Intestine. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 293(7), 1175-1183., Doi: 10.1002/ar.21163

14. Kim Hyun-Seok, Patel Krish, Muldoon-Jacobs Kristi, Bisht Kheem S, Aykin-Burns Nukhet, Pennington J Daniel, van der Meer, Nguyen Phuongmai, Savage Jason, Owens Kjerstin M, Vassilopoulos Athanassios, OZDEN OZKAN, Park Seong-Hoon, Singh Keshav K, Sarki A Abdulkadir, Spitz Douglas R, Deng Chu-Xia, Gius David (2010). SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress. Cancer Cell, 17(1), 41-52., Doi: 10.1016/j.ccr.2009.11.023.

15. Tipsmark C K, Baltzegar D A, OZDEN OZKAN, Grubb Brenda J, Borski Russell J (2008). Salinity regulates claudin mRNA and protein expression in the teleost gill. AJP: Regulatory, Integrative and Comparative Physiology, 294(3), 1004-1014., Doi: 10.1152/ajpregu.00112.2007.

 

International Conference Presentations:

1. Baltzegar David,OZDEN OZKAN,Borski Russell J (2009). Claudin mRNA expression in Mozambique tilapia (Oreochromis mossambicus) gill tissue: implications for osmoregulation and salinity adaptation. INTEGRATIVE AND COMPARATIVE BIOLOGY, 49, 9-9.

2. OZDEN OZKAN,Bishehsari Faraz,Bauer Jessica,Baik Seung Hyun,Jana Arundhati,Jung Barbara (2015). Expression of BARD1 splice variant impairs homologous recombination and can predict PARP1 inhibitor therapy in colon cancer. Cancer Research Forum (UIC-Chicago), 10-10.

3. OZDEN OZKAN,Bishehsari Faraz,Bauer Jessica,Baik Seung Hyun,Jung Barbara (2015). Expression of BARD1 splice variant impairs homologous recombination and can predict PARP1 inhibitor therapy in colorectal cancer.. American Association for Cancer Research (AACR), 75 (15 Supplement), 3626-3626., Doi: 10.1158/1538-7445.AM2015-3626.

4. Bauer Jessica I, Akagi Naomi, OZDEN OZKAN, Principe Daniel R, Carroll Timothy, Baik Seung Hyun, Spehlmann Martina E, Eckmann Lars, Grippo Paul J, Jung Barbara (2015). Opposing influence of activin and TGFb on PI3K and MEK/ERK signaling in colon cancer. American Association for Cancer Research (AACR) 106th Annual Meeting 2015, 75(15 Supplement), 1438-1438., Doi: 10.1158/1538-7445.AM2015-1438.

5. Jana Arundhati, Baik Seung Hyun, Carroll Timothy, OZDEN OZKAN, Krett Nancy L, Jung Barbara (2015). The NF-kB/MDM2 pathway is engaged in activin/ PI3 kinase induced degradation of p21 in colon cancer cells. American Association for cancer research (AACR), 75(15 Supplement), 42-42., Doi: 10.1158/1538-7445.AM2015-42.

6. Tao Randa, Bisht Kheem S, Nguyen Phuongma, ÖZDEN ÖZKAN, Gius David (2010). Posttranslational Regulation of Superoxide Dismutase as a Tumor-suppressor Effect of SIRT3. American Society for Radiation Oncology (ASTRO) 52nd Annual Meeting. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3), 89, Doi: 10.1016/j.ijrobp.2010.07.238.

7. OZDEN OZKAN, Black Betty, Brizuela Brenda (2005). Novel localization of claudin-16 tight junction protein in the goblet cells of chick. 64th Annual Meeting of the Society-for-Development-Biology, 283(2), 696-696., Doi: 10.1016/j.ydbio.2005.04.041 (Poster).

8. OZDEN OZKAN, Betty L Black, Brizuela Brenda (2004). Novel Role of claudin 16 tight junction protein in the goblet cells of chick intestine. Molecular Biology of the Cell - (ASBC), 15(S), 68-69.

Lisans Ankara Universitesi, Biyoloji, 1996-2000
Yüksek Lisans North Carolina State University, U.S.A., Biyoloji-Fizyoloji, 2003-2004
Doktora North Carolina State University, U.S.A., Biyoloji-Biyoteknoloji, 2005-2009
Post Doktora National Institute of Health (NIH), NCI, U.S.A., 2009-2010 Vanderbilt University, Medical Center, U.S.A., 2010-2012 Northwestern University, Lurie Cancer Center, U.S.A., 2012-2014
Yrd.Doç.Dr. University of Illinois at Chicago, U.S.A., Gastroenterology 2014 Kafkas Universitesi, 2016
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